Tetrahedron Letters

1-[2-(Trimethylsilyl) ethoxy] ethyl (SEE): A novel hybrid hydroxy-protecting group between 1-(ethoxy) ethyl (EE) and 2-(trimethylsilyl) ethoxymethyl (SEM)

J Wu, BK Shull, M Koreeda

文献索引：Wu, Junjun; Shull, Brian K.; Koreeda, Masato Tetrahedron Letters, 1996 , vol. 37, # 21 p. 3647 - 3650

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被引用次数: 9

摘要

The highly versatile 1-[(2-trimethylsilyl) ethoxy] ethyl (SEE) group, readily obtainable from an alcohol and 2-(trimethylsilyl) ethyl vinyl ether in the presence of a catalytic amount of PPTS, has been developed for the protection of hydroxyl groups. Its deprotection can be achieved under virtually neutral conditions with the use of a fluoride ion source, thus allowing for effective protection of hydroxyl groups of compounds that contain acid-and/or base- ...