4′-Alkoxyl substitution enhancing the anti-mitotic effect of 5-(3′, 4′, 5′-substituted) anilino-4-hydroxy-8-nitroquinazolines as a novel class of anti-microtubule …

Y Jin, ZY Zhou, W Tian, Q Yu, YQ Long

文献索引：Jin, Yi; Zhou, Zu-Yu; Tian, Wei; Yu, Qiang; Long, Ya-Qiu Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5864 - 5869

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被引用次数: 23

摘要

Mitosis inhibitors are powerful anticancer drugs. Based on a novel anti-microtubule agent of 5-(4′-methoxy) anilino-4-hydroxy-8-nitroquinazoline, a series of 5-(3′, 4′, 5′- substituted) anilino-4-hydroxy-8-nitroquinazolines were designed and synthesized to ...