前往化源商城

A General Synthetic Approach to the (20S)??Camptothecin Family of Antitumor Agents by a Regiocontrolled Cascade Radical Cyclization of Aryl Isonitriles

H Josien, SB Ko, D Bom…

文献索引：Josien, Hubert; Ko, Sung-Bo; Bom, David; Curran, Dennis P. Chemistry - A European Journal, 1998 , vol. 4, # 1 p. 67 - 83

全文：HTML全文

被引用次数: 183

摘要

Abstract The power of radical reactions continues to increase! A cascade radical annulation route now allows perhaps the mildest and most general method for the synthesis of both known and new members of the camptothecin family (parent structure on the right) of antitumor agents.

 相关合成线路
(S)-4,11-Diethyl-4-hydroxy-9-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione结构式

86639-53-4

(S)-4,11-Diethy...

~92%

7-乙基-10羟基喜树碱结构式

86639-52-3

7-乙基-10羟基喜树碱

(20S)-10,11-methylenedioxy-12-trimethylsilylcamptothecin结构式

202745-09-3

(20S)-10,11-met...

~78%

(S)-7-乙基-7-羟基-7H-[1,3]二氧杂环戊烯并[4,5-g]吡喃并[3',4':6,7]吲哚并[1,2-b]喹啉-8,11(10H,13H)-二酮结构式

135415-73-5

(S)-7-乙基-7-羟基-7...

胡椒醛结构式

120-57-0

胡椒醛

~%

(S)-7-乙基-7-羟基-7H-[1,3]二氧杂环戊烯并[4,5-g]吡喃并[3',4':6,7]吲哚并[1,2-b]喹啉-8,11(10H,13H)-二酮结构式

135415-73-5

(S)-7-乙基-7-羟基-7...

(S)-4-ethyl-4-hydroxy-6-iodo-3-oxo-1H-pyrano[3,4-c]-8-pyridone结构式

173442-34-7

(S)-4-ethyl-4-h...

~%

(S)-7-乙基-7-羟基-7H-[1,3]二氧杂环戊烯并[4,5-g]吡喃并[3',4':6,7]吲哚并[1,2-b]喹啉-8,11(10H,13H)-二酮结构式

135415-73-5

(S)-7-乙基-7-羟基-7...

(S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-propargyl-1H-pyrano[3,4-c]-8-pyridone结构式

174092-80-9

(S)-4-Ethyl-4-h...

~%

(S)-7-乙基-7-羟基-7H-[1,3]二氧杂环戊烯并[4,5-g]吡喃并[3',4':6,7]吲哚并[1,2-b]喹啉-8,11(10H,13H)-二酮结构式

135415-73-5

(S)-7-乙基-7-羟基-7...

(S)-4-Ethyl-4-hydroxy-6-iodo-8-Methoxy-1,4-dihydro-pyrano[3,4-c]pyridin-3-one结构式

174092-79-6

(S)-4-Ethyl-4-h...

~%

(S)-7-乙基-7-羟基-7H-[1,3]二氧杂环戊烯并[4,5-g]吡喃并[3',4':6,7]吲哚并[1,2-b]喹啉-8,11(10H,13H)-二酮结构式

135415-73-5

(S)-7-乙基-7-羟基-7...

4-(trimethylsilyl)benzo[d][1,3]dioxole-5-carbaldehyde结构式

181780-65-4

4-(trimethylsil...

~%

(S)-7-乙基-7-羟基-7H-[1,3]二氧杂环戊烯并[4,5-g]吡喃并[3',4':6,7]吲哚并[1,2-b]喹啉-8,11(10H,13H)-二酮结构式

135415-73-5

(S)-7-乙基-7-羟基-7...

(+/-)-4-ethyl-4-hydroxy-8-methoxy-6-(trimethylsilyl)-1,4-dihydro-3H-pyrano[3,4-c]pyridin-3-one结构式

869097-09-6

(+/-)-4-ethyl-4...

~%

(S)-7-乙基-7-羟基-7H-[1,3]二氧杂环戊烯并[4,5-g]吡喃并[3',4':6,7]吲哚并[1,2-b]喹啉-8,11(10H,13H)-二酮结构式

135415-73-5

(S)-7-乙基-7-羟基-7...

3-(1-羟乙基)苯胺结构式

2454-37-7

3-(1-羟乙基)苯胺

甲酸乙酯结构式

109-94-4

甲酸乙酯

~%

Formamide, N-[3-(1-hydroxyethyl)phenyl]- (9CI)结构式

321898-62-8

Formamide, N-[3...

未登录结构式

1197040-29-1

未登录

(S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-propargyl-1H-pyrano[3,4-c]-8-pyridone结构式

174092-80-9

(S)-4-Ethyl-4-h...

~61%

喜树碱结构式

7689-03-4

喜树碱

未登录结构式

1197040-29-1

未登录

(S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-allyl-1H-pyrano[3,4-c]-8-pyridone结构式

202745-20-8

(S)-4-Ethyl-4-h...

~20%

喜树碱结构式

7689-03-4

喜树碱

10-甲氧基喜树碱结构式

19685-10-0

10-甲氧基喜树碱

~84%

(S)-10-羟基喜树碱结构式

19685-09-7

(S)-10-羟基喜树碱

(S)-4-Ethyl-4-hydroxy-6-iodo-3-oxo-7-(2-pentynyl)-1H-pyrano[3,4-c]-8-pyridone结构式

174092-83-2

(S)-4-Ethyl-4-h...

[1,4'] Bipiperidinyl-1'-carboxylic acid 4-isonitrilo-phenylester结构式

202744-81-8

[1,4'] Bipiperi...

~31%

伊立替康结构式

97682-44-5

伊立替康

未登录结构式

202745-28-6

未登录

~85%

10-氨基喜树碱结构式

86639-63-6

10-氨基喜树碱


首页 |  期刊大全 |  MSDS查询 |  化工产品分类 |  生物活性化合物 |  关于我们 |  免责声明:知识产权问题请联系 service1@chemsrc.com
Copyright © 2024 ChemSrc All Rights Reserved