Tetrahedron

Turbotoxins A and B, novel diiodotyramine derivatives from the Japanese gastropod Turbo marmorata

H Kigoshi, K Kanematsu, K Yokota, D Uemura

文献索引：Kigoshi, Hideo; Kanematsu, Kengo; Yokota, Kyoko; Uemura, Daisuke Tetrahedron, 2000 , vol. 56, # 46 p. 9063 - 9070

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被引用次数: 20

摘要

Bioassay-guided separation of the aqueous ethanol extract of the viscera of the Japanese gastropod Turbo marmorata resulted in the isolation of two toxins, turbotoxins A and B. Their structures were determined by spectral analysis and confirmed by organic synthesis to be diiodotyramine derivatives. Turbotoxins A and B exhibited acute toxicity against ddY mice, with LD99 values of 1.0 and 4.0 mg/kg, respectively. The structure–toxicity relationships of ...