Structure–activity studies on 4-substituted-2-anilinopyrimidine corticotropin releasing factor (CRF) antagonists

PJ Gilligan, L He, S Culp, L Fitzgerald, SW Tam…

文献索引：Gilligan, Paul J.; He, Liqi; Culp, Steven; Fitzgerald, Lawrence; Tam, S.William; Wong, Y.Nancy Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 11 p. 2321 - 2328

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被引用次数: 16

摘要

Structure–activity studies around the 4-position of 2-anilinopyrimidine corticotropin releasing factor (CRF) antagonists suggest that there is a large lipophilic cavity in the rat CRF receptor, which can accommodate a wide variety of substituents at this position in contrast to the steric constraints observed for other positions on the 2-anilinopyrimidine core. The chemical syntheses and biological activities of 2-anilinopyrimidine CRF antagonists with carbon- ...