Synthesis and antiviral activity of (E)-5-(2-bromovinyl) uracil and (E)-5-(2-bromovinyl) uridine

E De Clercq, C Desgranges, P Herdewijn…

文献索引：Clercq, Erik De; Desgranges, Claude; Herdewijn, Piet; Sim, Iain S.; Jones, A. Stanley; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 2 p. 213 - 217

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被引用次数: 60

摘要

(E)-5-(2-Bromovinyl) uracil (BVU) and (E)-5-(2-bromovinyl) uridine (BVRU) were synthesized starting from 5-formyluracil via (E)-5-(2-~ arboxyvinyl) uracil or starting from 5- iodouridine via (E)-5-(2-carbomethoxyvinyl) uridine and (E)-5-(2-carboxyvinyl)~ idine, respectively. Depending on the choice of the cell system, BW and BVRU exhibited a marked activity against herpes simplex virus type 1 (HSV-1) in vitro. Although BW and BVRU were ...