Synthesis and anticancer potential of benzothiazole linked phenylpyridopyrimidinones and their diones as mitochondrial apoptotic inducers

Ä Kamal, M Ashraf, MV Vardhan, S Faazil…

文献索引：Kamal, Aehmed; Ashraf, Md.; Vishnu Vardhan; Faazil, Shaikh; Nayak, V. Lakshma Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 1 p. 147 - 151

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被引用次数: 6

摘要

Abstract A series of benzothiazole linked phenylpyridopyrimidinones (8a–g) and their diones (9a–g) have been designed, synthesized and evaluated for their anticancer activity. Among the series one of the conjugate 8b showed significant cytotoxicity against human cervical cancer cell line ME-180 with IC 50 value of 4.01 μM. This compound was tested on the cell cycle perturbations and DNA damage. Flow cytometry analysis revealed that the ...