To study the chemical constituents of Phryma leptostachya.The chemical constituents were isolated and purified by silica gel column, recrystallization and Pre-RP-HPLC and their structwes were elucidated by spectroscopic methods.Five compounds were obtained and identified as ursolic acid (1), quercetin (2), isovanillic acid (3), p-hydroxybenzoic acid (4), adenine arabinoside (5).Compounds 2 - 5 are isolated from this genus for the first time.