Zeitschrift fuer Naturforschung. Section C 2011-01-01

Synthesis and cytotoxic activities of new fatty acid esters of 20(S)-protopanaxadiol.

Ning Li, Yuan Huang, Wan Xiao, Jinping Liu, Xian Li, Pingya Li

文献索引：Z. Naturforsch., C, J. Biosci. 66(5-6) , 199-204, (2011)

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摘要

In order to find new lead compounds with antitumour activies, thirteen new fatty acid esters of 20(S)-protopanaxadiol (PPD) were synthesized using oleoyl chloride or fatty acids and N,N'-dicyclohexylcarbodiimide (DCC). Their cytotoxic activities were tested using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] method, and the structure-activity relationships between the fatty acid esters of PPD and their cytotoxic activities are discussed.