Antimycobacterial activity of new 3, 5-disubstituted 1, 3, 4-oxadiazol-2 (3H)-one derivatives. Molecular modeling investigations

D Zampieri, MG Mamolo, E Laurini, M Fermeglia…

文献索引：Zampieri, Daniele; Mamolo, Maria Grazia; Laurini, Erik; Fermeglia, Maurizio; Posocco, Paola; Pricl, Sabrina; Banfi, Elena; Scialino, Giuditta; Vio, Luciano Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4693 - 4707

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被引用次数: 30

摘要

3H-1, 3, 4-Oxadiazol-2-one derivatives were synthesized and tested for their in vitro antimycobacterial activity. Oxadiazolone derivatives showed an interesting antimycobacterial activity against the reference strain of Mycobacterium tuberculosis H37Rv. Molecular modeling investigations were performed and showed that the active compounds possess all necessary features to target the protein active site of the mycobacterial ...