Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase

…, E Chinje, IJ Stratford, KT Douglas, S Freeman

文献索引：Reigan, Philip; Gbaj, Abdul; Chinje, Edwin; Stratford, Ian J.; Douglas, Kenneth T.; Freeman, Sally Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5247 - 5250

全文：HTML全文

被引用次数: 20

摘要

A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase has been designed and synthesised to introduce tumour selectivity. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor.