Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists

X Zhang, H Hufnagel, T Markotan, J Lanter…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 18 p. 5577 - 5582

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被引用次数: 17

摘要

... Bioorganic & Medicinal Chemistry Letters. ... 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32 and 33 Of all reported chemical series, many CCR2 antagonists fall into a general class with a 'sandwich' structure consisting of a central basic amine flanked by two hydrophobes. ...