Steroids 1996-06-01

Synthesis of oxido-bridged analogs of 18-hydroxyprogesterone.

M O Doctorovich, A A Ghini, G Burton

文献索引：Steroids 61(6) , 345-8, (1996)

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摘要

18-Hydroxy-6,19-oxidoprogesterone and 18-hydroxy-11, 19-oxidoprogesterone were synthesized from readily available materials. The functionalization of C-18 was accomplished with phenyliodosodiacetate/iodine, whereas that of C-19 was carried out with the mercuric oxide/iodine system, both under irradiation with visible light. For 18-hydroxy-11,19-oxidoprogesterone, C-19 was functionalized before C-18, whereas the reverse order had to be used for the 6,19-oxido derivative.