Tetrahedron

Isoxazoles-mediated synthesis of geiparvarin and dihydrogeiparvarin

…, A Barco, S Benetti, A Casolari, S Manfredini…

文献索引：Baraldi, P. G.; Barco, A.; Benetti, S.; Casolari, A.; Manfredini, S.; et al. Tetrahedron, 1988 , vol. 44, # 4 p. 1267 - 1272

全文：HTML全文

被引用次数: 9

摘要

A new synthesis of geiparvarin 1 and its dihydroderivative 2 two naturally occurring antitumor agents, possessing the 3 (2H)-furanone ring system central structural feature, is described. The synthetic design is based on the use of suitably substituted isoxazole derivatives, the heterocyclic ring acting as masked 1, 3-diketone moiety.