Bioorganic & Medicinal Chemistry Letters 2000-10-02

Expeditious synthesis and cytotoxic activity of new cyanoindolo[3,2-c]quinolines and benzimidazo[1,2-c]quinazolines.

C Lamazzi, S Léonce, B Pfeiffer, P Renard, G Guillaumet, C W Rees, T Besson

文献索引：Bioorg. Med. Chem. Lett. 10 , 2183, (2000)

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摘要

Novel 6-cyanoindolo[3,2-c]quinoline and 6-cyanobenzimidazo[1,2-c]quinazoline derivatives have been synthesised by treatment of the appropriate aromatic amines with 4.5-dichloro-1,2,3-dithiazolium chloride 1 (Appel salt). The cytotoxicity and the effect of these compounds on cellular growth were measured.