International Journal of Pharmaceutics 2010-09-15

Influence of supercritical CO(2) pressurization on the phase behavior of mixed cholesteryl esters.

Zhen Huang, Mei Feng, Junfeng Su, Yuhua Guo, Tie-Yan Liu, Yee C Chiew

文献索引：Int. J. Pharm. 397(1-2) , 130-5, (2010)

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摘要

Evidences indicating the presence of phase transformations in the mixed cholesteryl benzoate (CBE) and cholesteryl butyrate (CBU) under the supercritical CO(2) pressurization, by means of differential scanning calorimetry (DSC) and X-ray diffraction (XRD), are presented in this work. These include (1) the DSC heating curve of pure CBU; (2) the DSC heating curves of CBU/CBE mixtures; (3) the XRD spectra of pure CBU; (4) the XRD spectra of CBU/CBE mixtures; (5) CBU and CBE are miscible in either solid phase or liquid phase over the whole composition range. As a result of the presence of these phase transformations induced by pressurization, it could be deduced that a solid solution of the CBU/CBE mixture might have formed at the interfaces under supercritical conditions, subsequently influencing their dissolving behaviors in supercritical CO(2).Copyright 2010 Elsevier B.V. All rights reserved.