Tetrahedron

The total synthesis of chlorophyll a

…, JM Beaton, F Bickelhaupt, R Bonnett, P Buchschacher…

文献索引：Woodward, Robert Burns; Ayer, William A.; Beaton, John M.; Bickelhaupt, Friedrich; Bonnett, Raymond; Buchschacher, Paul; Closs, Gerhard L.; Dutler, Hans; Hannah, John; Hauck, Fred P.; Ito, Sho; Langemann, Albert; Le Goff, Eugene; Leimgruber, Willy; Lwowski, Walter; Sauer, Juergen; Valenta, Zdenek; Volz, Heinrich Tetrahedron, 1990 , vol. 46, # 22 p. 7599 - 7659

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被引用次数: 98

摘要

The total synthesis of chlorophyll a starting from Knorr's pyrrole (1) is described with full experimental detail. Forty six stages are involved to reach the target molecule, chlorin e6 trimethyl ester (46), from which the preparation of chlorophyll a has already been described. The four pyrroles which are required for rings A, B, C and D are elaborated largely by known reactions, although with considerable improvements. These pyrroles are manipulated to ...