Convenient synthesis of 2-aminothiophene derivatives by acceleration of Gewald reaction under ultrasonic aqueous conditions

MM Mojtahedi, MS Abaee, P Mahmoodi…

文献索引：Mojtahedi, Mohammad M.; Abaee, M. Saeed; Mahmoodi, Peyman; Adib, Mehdi Synthetic Communications, 2010 , vol. 40, # 14 p. 2067 - 2074

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被引用次数: 16

摘要

Under ultrasound irradiation and in the presence of H2O/Et2NH, ethyl cyanoacetate or malononitrile can combine with α-methylene carbonyl compounds and elemental sulfur to efficiently yield 2-aminothiophene derivatives within a few minutes. Products are easily obtained by simple filtration because of their spontaneous precipitation in the reaction mixtures.