RhI??Catalyzed Hydration of Organonitriles under Ambient Conditions

A Goto, K Endo, S Saito

文献索引：Goto, Akihiro; Endo, Kohei; Saito, Susumu Angewandte Chemie - International Edition, 2008 , vol. 47, # 19 p. 3607 - 3609

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被引用次数: 116

摘要

The hydration of organonitriles is a reaction of great synthetic significance for the preparation of organoamides (eg, acrylamide and nicotinamide) in view of its broad industrial and pharmacological applications.[1] For example, hydration of acrylonitrile is used to produce more than 2 105 tons of acrylamide per year.[2] Classically the reaction proceeds in a sequence of distinct steps upon treatment with strong inorganic acid or base ...