Synthesis and octopaminergic-agonist activity of 3-(substituted phenyl) imidazolidine-2-thiones and related compounds

…, K Shinkai, E Kuwano, E Taniguchi, M ETO

文献索引：Hirashima, Akinori; Shinkai, Kenji; Kuwano, Eiichi; Taniguchi, Eiji; Eto, Morifusa Bioscience, Biotechnology and Biochemistry, 1998 , vol. 62, # 6 p. 1179 - 1184

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被引用次数: 14

摘要

3-(Substituted phenyl) imidazolidine-2-thiones (SPITs) and related compounds were synthesized by cyclizing monoethanolamine hydrogen sulfate with arylisothiocyanates in the presence of sodium hydroxide. The activity for stimulating adenylate cyclase prepared from thoracic nerve cords of the American cockroach, Periplaneta americana L., was examined with these compounds. A SPIT with a 2, 6-diethylphenyl group (48) was the only full ...