Catalytic asymmetric synthesis of both syn-and anti-β-amino alcohols

S Kobayashi, H Ishitani, M Ueno

文献索引：Kobayashi; Ishitani; Ueno Journal of the American Chemical Society, 1998 , vol. 120, # 2 p. 431 - 432

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被引用次数: 251

摘要

β-Amino alcohol units are often observed in biologically interesting compounds, and several methods for the synthesis of these units have been developed. 1-5 Among them, catalytic asymmetric processes are the most effective and promising. Asymmetric ring opening of symmetric epoxides by nitrogen nucleophiles in the presence of a chiral Lewis acid catalyst2 and ring opening of chiral epoxides or aziridines, which are prepared by catalytic ...