The in situ reductive amination of ketones or aldehydes has been an important part of the synthetic chemist's repertoire since the introduction of a procedure based on cyanoborohydride, l yet the toxicity and disposal problems associated with this material has led to a continuing search for alternative reductant^.^" We would like to report a simple and mild in situ reductive amination protocol using methanolic pyridine-borane and 4 A ...
