Biochimica et Biophysica Acta 1997-02-04

Oocyte and zygote ketoaldehyde utilisation.

M Legge

文献索引：Biochim. Biophys. Acta 1355(2) , 99-101, (1997)

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摘要

Mouse oocytes and zygotes, when solubilised demonstrated that a range of ketoaldehydes could be utilised as substrates. Of the five ketoaldehydes investigated the overall substrate utilisation was hydroxypyruvate > glyoxylate > 2-ketobutyrate > pyruvate > glycolate. The utilisation of these ketoaldehydes during early development by LD-1 may provide a source of new metabolic substrates in addition to the potential control of aldehyde toxicity. It is proposed therefore that the LD-1 isoenzyme is responsible for ketoaldehyde utilisation prior to implantation thereby providing a source of alternative metabolic substrates for the developing embryo.