Clinical Chemistry 1986-06-01

Simplified liquid-chromatographic determination of vancomycin.

A F Rosenthal, I Sarfati, E A'Zary

文献索引：Clin. Chem. 32(6) , 1016-9, (1986)

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摘要

We simplified determination of vancomycin in serum by using a direct and rapid solvent precipitation of protein and by using a simple organic compound as internal standard. Reproductibility of the vancomycin retention time was improved by modifying the mobile phase. Data obtained by fluorescence polarization immunoassay correlated well, and there was little bias between the two methods. The present method is sufficiently rapid to make this a practical choice for many laboratories.