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Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents

RP Tangallapally, R Yendapally, RE Lee…

文献索引:Tangallapally, Rajendra P.; Yendapally, Raghunandan; Lee, Robin E.; Hevener, Kirk; Jones, Victoria C.; Lenaerts, Anne J. M.; McNeil, Michael R.; Wang, Yuehong; Franzblau, Scott; Lee, Richard E. Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5276 - 5283

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被引用次数: 68

摘要

In an ongoing effort to develop new and potent antituberculosis agents, a second-generation series of nitrofuranyl amides was synthesized on the basis of the lead compound 5- nitrofuran-2-carboxylic acid 3, 4-dimethoxybenzylamide. The primary design ...