Peroxisome proliferator-activated receptor-γ mediates the anti-inflammatory effect of 3-hydroxy-4-pyridinecarboxylic acid derivatives: Synthesis and biological …

…, A Dean, V Di Marco, P Surajit, I Castagliuolo…

文献索引：Brun, Paola; Dean, Annalisa; Di Marco, Valerio; Surajit, Pathak; Castagliuolo, Ignazio; Carta, Davide; Ferlin, Maria Grazia European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 486 - 497

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被引用次数: 14

摘要

Seven 3-hydroxy-4-pyridinecarboxylic acid derivatives (HPs), aza-analogues of salicylic acid and structurally close to other potent inflammatory pyridine compounds such as aminopyridinylmethanols and aminopyridinamines, were synthesized, and their anti- inflammatory activity was evaluated. The synthesis was performed by adopting a general procedure involving an intramolecular Diels–Alder cycloaddition of oxazoles with acrylic ...