Synlett

Preparation of monofluorophenols via the reaction of difluorobenzene derivatives with potassium trimethylsilanoate

J Li, D Smith, JX Qiao, S Huang, S Krishnananthan…

文献索引：Li, Jianqing; Smith, Daniel; Qiao, Jennifer X.; Huang, Stella; Krishnananthan, Subramaniam; Wong, Henry S.; Salvati, Mark E.; Balasubramanian, Balu N.; Chen, Bang-Chi Synlett, 2009 , # 4 p. 633 - 637

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被引用次数: 3

摘要

The conversion of widely available aryl fluorides to the corresponding phenols has been recognized as an important and useful transformation. The common method involves replacement of a fluorine atom of an electron-deficient aryl fluoride with a variety of alkoxies as 'masked' hydroxy groups followed by cleavage of the resulting aryl alkyl ether in a stepwise or one-pot fashion. [³a] [b] Although the hydroxy ion has been shown to be able to replace fluorine atom in certain ...