Fragment based discovery of a novel and selective PI3 kinase inhibitor

SJ Hughes, DS Millan, IC Kilty, RA Lewthwaite…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6586 - 6590

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被引用次数: 20

摘要

... Bioorganic & Medicinal Chemistry Letters. ... a Worldwide Medicinal Chemistry, Pfizer Global ... biochemical assay led to the identification of a weakly potent, but LE amino pyrazolopyrimidine fragment hit 1. Close in virtual screening allowed exploration of chemical space around this ...