Organic Letters 2003-10-30

Synthetic studies toward FR182877. Remarkable solvent effect in the vinylogous morita-baylis-hillman cyclization.

Joey L Methot, William R Roush

文献索引：Org. Lett. 5(22) , 4223-6, (2003)

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摘要

[reaction: see text]. The intramolecular vinylogous Morita-Baylis-Hillman reaction was explored to access the central cyclopentane ring of FR182877. The reaction manifold and product distribution is strikingly solvent and substrate dependent.