Synthesis of a New Family of N??Aryl Lactams Active on Chemesthesis and Taste

A Bassoli, G Borgonovo, G Busnelli…

文献索引：Bassoli, Angela; Borgonovo, Gigliola; Busnelli, Gilberto; Morini, Gabriella European Journal of Organic Chemistry, 2006 , # 7 p. 1656 - 1663

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被引用次数: 10

摘要

Abstract A new class of synthetic compounds with chemesthetic activity has been identified. They have been designed ex-novo by structural similarity with known cooling compounds such as menthol, icilin and cyclic ketoenamines. 19 new derivatives have been obtained easily and in high yields by Goldberg arylation or lactam ring closure on the appropriate phenol or benzoic acid derivative. The synthetic procedures are suitable for gram-scale ...