Tetrahedron

Synthesis of isoquinolines and tetrahydroisoquinolines as potential antitumour agents

…, M Romero, MD Pujol, DH Caignard, P Renard

文献索引：Capilla; Romero; Pujol; Caignard; Renard Tetrahedron, 2001 , vol. 57, # 39 p. 8297 - 8303

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被引用次数: 41

摘要

The isoquinoline 17 and the tetrahydroisoquinoline 16 were synthesized from 2, 3-dihydro- 1, 4-benzodioxin (1) by different synthetic strategies. Preparation of arylethylamines and their cyclization in Bischler–Napieralski conditions have been studied. Another approach to isoquinolines was based on the amination of the ketone 13 followed by cyclization in acidic media. The route via the amide 15 was found to be more successful with respect to both ...