Simple mixed Fe–Zn catalysts for the Suzuki couplings of tetraarylborates with benzyl halides and 2-halopyridines

RB Bedford, MA Hall, GR Hodges, M Huwe…

文献索引：Bedford, Robin B.; Hall, Mark A.; Hodges, George R.; Huwe, Michael; Wilkinson, Mark C. Chemical Communications, 2009 , # 42 p. 6430 - 6432

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被引用次数: 35

摘要

The iron-catalysed Negishi coupling can be extended to 2-halopyridine and pyrimidine substrates, as summarised briefly in Table 1. 6 † Good activity was observed in toluene–THF mixtures; pure THF led to poorer results. Increasing the amount of ditolylzinc beyond 1.2 equiv. gave higher yields of product but also led to substantial quantities of bitolyl impurity. The presence of the catalyst proved to be essential for activity (entry 4). Only 2-halopyridines ...