Intermolecular complexes formed between metalloporphyrins and pyridine ligands equipped with multiple H-bond donors and acceptors have been used to measure the free energy contributions due to intramolecular ether–phenol H-bonding in the 24 different supramolecular architectures using chemical double mutant cycles in toluene. The ether– phenol interactions are relatively weak, and there are significant populations of partially ...
