A series of chromene derivatives was synthesized and evaluated for their in vitro and ex vivo 5-lipoxygenase (&LO) inhibitory activity. These compounds were prepared by condensation of appropriate salicyl aldehydes with a, P-unsaturated carbonyl compounds, followed by transformation to the corresponding hydroxamic acids or N-hydroxyureas. Placement of phenoxy or p-fluorophenoxy substituents at the 6 position of the chromene ring led to a ...
