Abstract: The methoxy group of o-anisic acid was cleaved with aliphatic amines in aprotic dipolar solvents. This cleavage reaction was especially smooth when piperazine in dimethylacetamide was used. This method was applicable to a variety of dealkylations of o- alkoxybenzoic acid and ist amide derivatives with high regioselectivity. Key words: amides, carboxylic acids, cleavage, ethers, regioselectivity, o-anisic acid
