The introduction of a double bond on the steroid skeleton–The preparation of enol silyl ether derivatives from vicinal diols

A Marek, B Klepetářová, T Elbert

文献索引：Marek, Ales; Klepetarova, Blanka; Elbert, Tomas Collection of Czechoslovak Chemical Communications, 2011 , vol. 76, # 5 p. 443 - 456

全文：HTML全文

被引用次数: 4

摘要

Abstract The ways of converting steroid vicinal diol into an unsaturated derivative were studied with the intention of preparing suitable precursors for the introduction of deuterium or tritium into the molecules of brassinosteroids. The model vicinal diol compound, 2α, 3α- dihydroxy-5α-pregnane-6, 20-dione (3), was converted with high regioselectivity to the α- hydroxy ketone derivative, 2α-hydroxy-5α-pregnane-3, 6, 20-trione (8), in a 75% yield. The ...