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Organic & biomolecular chemistry

An efficient one pot transfer hydrogenation and N-alkylation of quinolines with alcohols mediated by Pd/C/Zn

B Abarca, R Adam, R Ballesteros

文献索引:Abarca, Belen; Adam, Rosa; Ballesteros, Rafael Organic and Biomolecular Chemistry, 2012 , vol. 10, # 9 p. 1826 - 1833

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被引用次数: 9

摘要

A Pd/C/Zn mixture with alcohols has been revealed to be an efficient transfer hydrogenation system to quinolines. Furthermore, the metals mixture is able to activate alcohols as N- alkylating agents in a hydrogen autotransfer process. 1, 2, 3, 4-Tetrahydroquinolines and N- alkylated tetrahydroquinolines from quinolines have been obtained with excellent yields in one step.