Enzymatic and chemoenzymatic synthesis and stereochemical assignment of cis-dihydrodiol derivatives of monosubstituted benzenes

DR Boyd, ND Sharma, MV Hand, JF Malone…

文献索引：Boyd, Derek R.; Sharma, Narain D.; Byrne, Breige; Hand, Mark V.; Malone, John F.; Sheldrake, Gary N.; Blacker, John; Dalton, Howard Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 12 p. 1935 - 1943

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被引用次数: 60

摘要

Toluene dioxygenase-catalysed oxidation of mono-substituted benzene substrates (R= F, Cl, Br, I, Me, Et, CH2OAc, CH [[double bond, length half m-dash]] CH2, C [[triple bond, length half m-dash]] CH, CF3, CN, OMe, OEt, SMe) in growing cultures of Pseudomonas putida UV4 yielded the corresponding cis-dihydrodiol metabolites. Palladium-catalysed cross- coupling of cis-(1S, 2S [])-1, 2-dihydrox