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Syntheses and In Vitro Anticancer Properties of Novel Radiosensitizers

Z Ates??Alagoz, N Coleman, M Martin…

文献索引:Ates-Alagoz, Zeynep; Coleman, Natalia; Martin, Marlena; Wan, Aaron; Adejare, Adeboye Chemical Biology and Drug Design, 2012 , vol. 80, # 6 p. 853 - 861

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被引用次数: 1

摘要

Series of 4-(ethylsulfonyl)-1-halogen-2-nitrobenzene (3a–e) and 1-(4-halogen-3- nitrophenyl) propan-1-one (5a–d) analogs designed as novel radiosensitizers using bromonitropropiophenone and bromonitrobenzonitrile as lead compounds were synthesized. The anticancer activities of the compounds were evaluated in vitro using human prostate cancer (DU-145) and breast cancer (MCF-7) cell lines and the MTT assay. ...