Tetrahedron letters

A concise, scaleable synthesis of narwedine

DA Chaplin, N Fraser, PD Tiffin

文献索引：Chaplin, David A.; Fraser, Neil; Tiffin, Peter D. Tetrahedron Letters, 1997 , vol. 38, # 45 p. 7931 - 7932

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被引用次数: 21

摘要

Abstract:. A concise, scalceblc synthesis of narwedine from 3,4-dimethoxybenzaldehyde is described. The procedure features a simple modification to the Barton phenolic coupling route. © 1997 Published by Elsevier Science Ltd. (-)-Galanthamine (1), is a natural product currently under evaluation for the treatment of AIzheimer's disease.' Isolation by extraction from bulbs, such as daffodils or snowdrops, is low yielding resulting in high costs and limited ...