Design, synthesis and structure–activity relationships of some novel, highly potent anti-invasive (E)-and (Z)-stilbenes

…, T De Ryck, BWA Vanhoecke, AR Katritzky…

文献索引：Roman, Bart I.; De Coen, Laurens M.; Mortier, Severine Therese F.C.; De Ryck, Tine; Vanhoecke, Barbara W.A.; Katritzky, Alan R.; Bracke, Marc E.; Stevens, Christian V. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5054 - 5063

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被引用次数: 9

摘要

Abstract In our ongoing exploration of the structure–activity landscape of anti-invasive chalcones, we have prepared and evaluated a number of structurally related (E)-and (Z)- stilbenes. These molecules exhibited an extraordinary high in vitro potency in the chick ...