Tetrahedron Letters

Regio-and stereoselective hydroxybromination and dibromination of olefins using ammonium bromide and oxone®

AK Macharla, RC Nappunni, N Nama

文献索引：MacHarla, Arun Kumar; Chozhiyath Nappunni, Rohitha; Nama, Narender Tetrahedron Letters, 2012 , vol. 53, # 11 p. 1401 - 1405

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被引用次数: 23

摘要

An efficient protocol for the synthesis of vicinal bromohydrins and dibromides from olefins is presented. Various olefins are regio-and stereoselectively hydroxybrominated and dibrominated with anti fashion, following Markonikov's rule, using eco-friendly, non-toxic, and stable reagents such as NH4Br and oxone® in CH3CN/H2O (1: 1) and CH3CN without employing catalyst in moderate to excellent yields. Bromohydrins are formed ...