Design, synthesis, and preliminary in vitro and in silico antiviral activity of [4, 7] phenantrolines and 1-oxo-1, 4-dihydro-[4, 7] phenantrolines against single-stranded …

…, S Pricl, T Sanna, C Ibba, P La Colla, R Loddo

文献索引：Carta, Antonio; Loriga, Mario; Paglietti, Giuseppe; Ferrone, Marco; Fermeglia, Maurizio; Pricl, Sabrina; Sanna, Tiziana; Ibba, Cristina; La Colla, Paolo; Loddo, Roberta Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 5 p. 1914 - 1927

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被引用次数: 31

摘要

Following the antiviral screening of a wide series of new angular and linear N-tricyclic systems both in silico and in vitro, the [4, 7] phenantroline nucleus emerged as a new ring system endowed with activity against viruses containing single-stranded, positive-sense RNA genomes (ssRNA+). Here, we report our new pathway to the synthesis of this nucleus and of several related derivatives, as well as the results of both cell-based antiviral assays ...