Tetrahedron letters

Efficient cleavage of carboxylic tert-butyl and 1-adamantyl esters, and N-Boc-amines using H 2 SO 4 in CH 2 Cl 2

P Strazzolini, N Misuri, P Polese

文献索引：Strazzolini, Paolo; Misuri, Nazareno; Polese, Pierluigi Tetrahedron Letters, 2005 , vol. 46, # 12 p. 2075 - 2078

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被引用次数: 22

摘要

A new procedure for the deprotection of carboxylic tert-butyl and 1-adamantyl esters, and N- Boc-amines using H2SO4 in CH2Cl2 is described. The proposed method is simple, cheap, eco-friendly and represents a valid alternative to existing ones, with special significance in large scale applications.