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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

New triazine derivatives as potent modulators of multidrug resistance

A Dhainaut, G Regnier, G Atassi, A Pierre…

文献索引：Dhainaut, Alain; Regnier, Gilbert; Atassi, Ghanem; Pierre, Alain; Leonce, Stephane; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2481 - 2496

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被引用次数: 88

摘要

A series of 70 triazine derivatives have been synthesized and teated for their capacity to modulate multidrug resistance (MDR) in DC-3F/AD and KB-A1 tumor cells in vitro, in comparison with verapamil (VRP), a calcium channel antagonist currently used in therapy as an antihypertensive drug, which also shows MDR modulating activity. Among the 12 selected compounds, 16 (S9788) showed high MDR reversing properties in vitro (300-and ...

6-chloro-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine结构式

6-chloro-2-N,4-...

1-(4,4'-二氟苯甲基)哌嗪结构式

1-(4,4'-二氟苯甲基)哌嗪

~%

阿米君结构式

bis(2,6-dimethylphenyl)methyl chloride结构式

bis(2,6-dimethy...

氰化银结构式

~%

bis(2,6-dimethylphenyl)acetonitrile结构式

bis(2,6-dimethy...

3-氯-6-甲基二苯并[c,f][1,2]硫氮杂卓-11(6H)-酮 5,5-二氧化物结构式

3-氯-6-甲基二苯并[c,f...

~%

rac 3,11-二氯-6,11-二氢-6-甲基-二苯并[c,f] [1,2]噻氮平5,5-二氧化物结构式

rac 3,11-二氯-6,1...

1-(4,6-bis(allylamino)-1,3,5-triazin-2-yl)-4-piperidone hydrochloride结构式

1-(4,6-bis(ally...

~%

N-[1-[4,6-bis(prop-2-enylamino)-1,3,5-triazin-2-yl]piperidin-4-ylidene]hydroxylamine结构式

N-[1-[4,6-bis(p...

4,4-二乙氧基哌啶结构式

4,4-二乙氧基哌啶

~%

N-[1-[4,6-bis(prop-2-enylamino)-1,3,5-triazin-2-yl]piperidin-4-ylidene]hydroxylamine结构式

N-[1-[4,6-bis(p...

6-chloro-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine结构式

6-chloro-2-N,4-...

~%

N-[1-[4,6-bis(prop-2-enylamino)-1,3,5-triazin-2-yl]piperidin-4-ylidene]hydroxylamine结构式

N-[1-[4,6-bis(p...

9-Chloro-9H-xanthene结构式

9-Chloro-9H-xanthene

氰化银结构式

~%

9-氰基呫吨结构式

2,2-双(4-氟苯基)乙胺结构式

2,2-双(4-氟苯基)乙胺

1-(4,6-bis(allylamino)-1,3,5-triazin-2-yl)-4-piperidone hydrochloride结构式

1-(4,6-bis(ally...

~54%

6-[4-[2,2-bis(4-fluorophenyl)ethylamino]piperidin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine结构式

6-[4-[2,2-bis(4...

4,4-二乙氧基哌啶结构式

4,4-二乙氧基哌啶

~%

6-[4-[2,2-bis(4-fluorophenyl)ethylamino]piperidin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine结构式

6-[4-[2,2-bis(4...

6-chloro-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine结构式

6-chloro-2-N,4-...

~%

6-[4-[2,2-bis(4-fluorophenyl)ethylamino]piperidin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine结构式

6-[4-[2,2-bis(4...

双(4-氟苯基)氯甲烷结构式

双(4-氟苯基)氯甲烷

~%

6-[4-[2,2-bis(4-fluorophenyl)ethylamino]piperidin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine结构式

6-[4-[2,2-bis(4...

4-fluoro-α-(4-fluorophenyl)benzeneacetonitrile结构式

4-fluoro-α-(4-f...

~%

6-[4-[2,2-bis(4-fluorophenyl)ethylamino]piperidin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine结构式

6-[4-[2,2-bis(4...

4,4-二乙氧基哌啶结构式

4,4-二乙氧基哌啶

~%

1-[2,6-bis(prop-2-enylamino)pyrimidin-4-yl]piperidin-4-one结构式

1-[2,6-bis(prop...

未登录结构式

~%

1-[2,6-bis(prop-2-enylamino)pyrimidin-4-yl]piperidin-4-one结构式

1-[2,6-bis(prop...

4-fluoro-α-(4-fluorophenyl)benzeneacetonitrile结构式

4-fluoro-α-(4-f...

~%

2,2-双(4-氟苯基)乙胺结构式

2,2-双(4-氟苯基)乙胺

双(4-氟苯基)氯甲烷结构式

双(4-氟苯基)氯甲烷

~%

2,2-双(4-氟苯基)乙胺结构式

2,2-双(4-氟苯基)乙胺

2-(4-甲氧基苯乙基)苯甲酸结构式

2-(4-甲氧基苯乙基)苯甲酸

~55%

2-甲氧基二苯并软木酮结构式

2-甲氧基二苯并软木酮