前往化源商城

Toxicology in Vitro 2015-12-01

Elucidating toxicological mechanisms of current flame retardants using a bacterial gene profiling assay.

Boris V Krivoshiev, Freddy Dardenne, Ronny Blust, Adrian Covaci, Steven J Husson

文献索引:Toxicol. In Vitro 29 , 2124-32, (2015)

全文:HTML全文

摘要

Flame retardants are ubiquitously used chemicals that have been shown to contaminate environments. Toxicological data is largely limited, with little insight into their molecular modes of action that may give rise to their toxic phenotypes. Such insight would aid more effective risk assessments concerning these compounds, while also improving molecular design. We therefore used a bacterial stress-gene profiling assay to screen twelve currently-used flame retardants to obtain mechanistic insights of toxicity. Both brominated and organophosphate flame retardants were tested. All compounds showed statistically significant inductions of several stress genes when compared to control treatments. Triphenyl phosphate, tris(2-butoxyethyl) phosphate, tris(1,3-dichloro-2-propyl)phosphate, tris(butyl)phosphate, and tetrabromobisphenol A elicited (at least) two-fold inductions for any of the stress genes. When looking at absolute induction levels, the promoters induced are indicative of protein perturbation, DNA integrity and membrane integrity. However, normalising for the different induction potentials of the different stress genes and clustering using hierarchical and k-means algorithms indicated that in addition to protein and DNA damage, some compounds also resulted in growth arrest and oxidative damage. This research shows that this assay allows for the determination of toxicological modes-of-action while clustering and accounting for induction potentials of the different genes aids better risk assessment. Copyright © 2015 Elsevier B.V. All rights reserved.

相关化合物

结构式 名称/CAS号 全部文献
磷酸三苯酯 结构式 磷酸三苯酯
CAS:115-86-6
二甲基亚砜 结构式 二甲基亚砜
CAS:67-68-5
磷酸三丁酯 结构式 磷酸三丁酯
CAS:126-73-8
四溴双酚A 结构式 四溴双酚A
CAS:79-94-7
三氯乙基磷酸酯 结构式 三氯乙基磷酸酯
CAS:115-96-8
六溴环十二烷 结构式 六溴环十二烷
CAS:3194-55-6
三丁氧基乙基磷酸酯 结构式 三丁氧基乙基磷酸酯
CAS:78-51-3
磷酸三乙酯 结构式 磷酸三乙酯
CAS:78-40-0
阻燃剂 结构式 阻燃剂
CAS:917-23-7
8-辛酰氧基芘-1,3,6-三磺酸三钠盐 结构式 8-辛酰氧基芘-1,3,6-三磺酸三钠盐
CAS:115787-84-3