Synthesis of indomethacin analogues for evaluation as modulators of MRP activity

…, SJ Plunkett, S Papot, M Clynes, R O'Connor…

文献索引：Maguire, Anita R.; Plunkett, Stephen J.; Papot, Sebastien; Clynes, Martin; O'Connor, Robert; Touhey, Samantha Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 745 - 762

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被引用次数: 35

摘要

To explore this effect and, in particular, to determine SAR in potentiating the toxicity of anticancer drugs, a range of indomethacin analogues was synthesised and their activity tested in our screens (hereafter described as combination toxicity assays). Indomethacin Figure 1, Scheme 4 and Scheme 6 was a logical candidate for investigation as its structure is very amenable to modification to establish the influence of the various substituents, for example the role of the 5-methoxy, ...