Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole

…, M Sakaitani, Y Shiratori, T Yamazaki, S Ichihara…

文献索引：Ohwada, Jun; Tsukazaki, Masao; Hayase, Tadakatsu; Oikawa, Nobuhiro; Isshiki, Yoshiaki; Fukuda, Hiroshi; Mizuguchi, Eisaku; Sakaitani, Masahiro; Shiratori, Yasuhiko; Yamazaki, Toshikazu; Ichihara, Shigeyasu; Umeda, Isao; Shimma, Nobuo Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 191 - 196

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被引用次数: 41

摘要

A highly potent water soluble triazole antifungal prodrug, RO0098557 (1), has been identified from its parent, the novel antifungal agent RO0094815 (2). The prodrug includes a triazolium salt linked to an aminocarboxyl moiety, which undergoes enzymatic activation ...