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Synthesis of 4-fluoro-β-(4-fluorophenyl)-L-phenylalanine by an asymmetric phase-transfer catalyzed alkylation: synthesis on scale and catalyst stability

DE Patterson, S Xie, LA Jones…

文献索引:Organic Process Research and Development, , vol. 11, # 3 p. 624 - 627

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被引用次数: 30

摘要

... Chemical Development, GlaxoSmithKline, Five Moore Drive, PO Box 13398, Research Triangle Park ... Org. Process Res. ... The organic solution was concentrated at atmospheric pressure to 10 L. The reactor was then charged with 23% ethyl acetate in heptane (9.1 L) and was ...