Tetrahedron letters

A new approach to the synthesis of thioether phospholipids. Preparation of 1-thiohexadecyl-2-N-acylaminodeoxyglycerophosphocholines

SK Bhatia, J Hajdu

文献索引：Bhatia, Suresh K.; Hajdu, Joseph Tetrahedron Letters, 1988 , vol. 29, # 1 p. 31 - 34

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被引用次数: 16

摘要

Thioether phospholipids are a new class of synthetic phospholipid analogues exhibiting high level of activity in a wide spectrum of biological systems. l-4 Included among these are a series of antitumor active thioalkyl derivatives of platelet activating factor (PAF) lW3 that have been shown to exceed the tumor-cytotoxicity of the corresponding oxygen compounds. 3 Furthermore, sulfur substitution at the m-1 position appears to lower the platelet- ...